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| Keywords | |
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hypocrellin B |
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photodynamic therapy |
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collagen |
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pyridinoline cross-link |
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fibrosis |
| Authors | |
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ZHANG JuCheng |
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LIU Wei |
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YI ZhongZhou |
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CHEN Rui |
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LI Ying |
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MIN Yong |
| PubMed | |
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Article by ZHANG JuCheng |
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Article by LIU Wei |
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Article by YI ZhongZhou |
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Article by CHEN Rui |
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Article by LI Ying |
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Article by MIN Yong |
The molecular mechanism of photodynamic therapy to fibrosis: Regulation on the pyridinoline cross-link formation in collagen
ZHANG JuCheng1,2, LIU Wei1,2, YI ZhongZhou1,2, CHEN Rui1,2, LI Ying1,2 &|MIN Yong1,2
1 Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, Honghe University, Mengzi 661100, China;
2 School of Science, Honghe University, Mengzi 661100, China
Fibrotic processes in tissues are characterised by an excessive accumulation of collagen containing increased levels of pyridinoline cross-links, which has been taken as an important criterion to diagnose the fibrosis. Hypocrellin B (HB) is a natural photosensitizer with excellent photodynamic activity but very low dark-toxicity. In the current work, main purpose was to clarify if photodynamic action of HB could be applied to regulating the level of pyridinoline cross-link in collagen. To use gelatin as a model collagen, it was observed that the pyridinoline cross-link formation was effectively degraded by HB photodynamic action in the gelatin, suggesting the level of pyridinoline cross-link formation in collagen may be photodynamically regulated to a normal level. Furthermore, mechanism of the photodynamic action of HB was studied.
Supported by the Natural Science Foundation of Yunnan Province (Grant No. 2005C0078M) and Scientific Research Startup Project Foundation of Honghe Uni-versity (Grant No. XSS07012)